{"id":131747,"date":"2021-09-07T06:00:00","date_gmt":"2021-09-07T06:00:00","guid":{"rendered":"https:\/\/icrowdnewswire.com\/?p=2908776"},"modified":"2021-09-07T06:00:00","modified_gmt":"2021-09-07T06:00:00","slug":"neuexcell-therapeutics-and-spark-therapeutics-announce-research-collaboration-agreement-to-develop-a-novel-gene-therapy-for-huntingtons-disease","status":"publish","type":"post","link":"https:\/\/ipsnews.net\/business\/2021\/09\/07\/neuexcell-therapeutics-and-spark-therapeutics-announce-research-collaboration-agreement-to-develop-a-novel-gene-therapy-for-huntingtons-disease\/","title":{"rendered":"NeuExcell Therapeutics and Spark Therapeutics Announce Research Collaboration Agreement to Develop a Novel Gene Therapy for Huntington\u2019s Disease"},"content":{"rendered":"<p><img decoding=\"async\" width=\"300\" height=\"69\" src=\"https:\/\/icrowdnewswire.com\/wp-content\/uploads\/2021\/09\/NeuExcell-1.jpg\" class=\"webfeedsFeaturedVisual wp-post-image\" alt=\"\" loading=\"lazy\" style=\"display: block; margin-bottom: 5px; clear:both;max-width: 100%;\" link_thumbnail=\"\" \/><\/p>\n<ul>\n<li><em>Using NeuExcell\u2019s neuroregenerative gene therapy platform, the collaboration aims to develop an effective and safe treatment for patients suffering from Huntington\u2019s Disease.<\/em><\/li>\n<li><em>Spark Therapeutic\u2019s excellence in R&amp;D and proprietary adeno-associated virus (AAV) vector gene therapy platform may advance the development of the program and overcome hurdles and challenges of viral vectors for gene therapy.<\/em><\/li>\n<li><em>NeuExcell is eligible to receive upfront, license fees, R&amp;D and Sales milestone payments up to approximately $190 million plus product royalties. <\/em><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>STATE COLLEGE and PHILADELPHIA, August 31, 2021 (GLOBE NEWSWIRE)<\/p>\n<p>NeuExcell Therapeutics and Spark Therapeutics, a member of the Roche Group (SIX: RO, ROG; OTCQX: RHHBY) today announced a gene therapy collaboration aimed at developing a safe and effective treatment for patients suffering from Huntington\u2019s Disease (HD).<\/p>\n<p>Under the terms of the agreement, Spark Therapeutics will receive access to NeuExcell\u2019s proprietary neuro-regenerative gene therapy platform and capabilities. NeuExcell\u2019s research team will collaborate closely with Spark Therapeutics to advance the program. Under the Option License NeuExcell is eligible to receive upfront, license fees, R&amp;D and Sales milestone payments up to approximately $190 million plus product royalties. Under this Agreement, Spark Therapeutics has the option to license the exclusive worldwide rights of the NeuExcell\u2019s HD program.<\/p>\n<p>\u201cWe are excited to collaborate with Spark Therapeutics. Their in-house know-how and capabilities to develop gene therapies that may have the potential to slow, halt or cure neurological diseases and seek to enhance the industry standard for AAV engineering, making them an ideal partner to accelerate our HD program\u201d said Ronald HW Lorijn, CEO of NeuExcell Therapeutics.<\/p>\n<p>\u201cSpark Therapeutics is always looking for ways to bring potentially groundbreaking therapies to patients, including those living with Huntington\u2019s Disease, to challenge the inevitability of genetic diseases. We are looking forward to our collaboration with NeuExcell and to explore their unique neuroregenerative gene therapy platform,\u201d said Federico Mingozzi, Ph.D., Chief Scientific Officer of Spark Therapeutics.<\/p>\n<p>The prevailing assumption has been that mammalian adult neurons cannot be replaced, and so therapeutic approaches for brain diseases tend to focus on slowing disease progress. NeuExcell Therapeutics may have unlocked the method for regenerating neural tissue. The company\u2019s neuroregenerative gene therapy platform is built around transcription factor-based trans-differentiation technology. The platform seeks to reprogram endogenous glial cells like astrocytes, which surround neurons and are often reactive after neurons are injured or die, into functional new neurons. While neurons cannot divide to regenerate themselves, glial cells are a renewable source for generating new neurons at the site of injury, and at the scale needed to have a meaningful therapeutic impact. NeuExcell is developing adeno-associated viruses (AAVs)-based neuroregenerative gene therapy to regenerate functional new neurons at the site of the neurodegeneration.<\/p>\n<p>\u201cAt Spark, we understand that in order to break down barriers for people and families affected by genetic diseases, we need to work with like-minded partners that can integrate innovative technologies with our advanced proprietary AAV vector platform,\u201d said Joseph La Barge, Chief Business Officer of Spark Therapeutics. \u201cUsing our existing expertise in gene therapy development and NeuExcell\u2019s neuro-regenerative gene therapy research and capabilities, together we can progress the potential of gene therapy for patients living with Huntington\u2019s Disease.\u201d<\/p>\n<p>Spark Therapeutic\u2019s advanced proprietary AAV vector platform targeted to the central nervous system offers the HD research and development (R&amp;D) program a major advantage. At the forefront of gene therapy research for more than two decades, Spark Therapeutics has extensive knowledge and capabilities in this field that it will use to bring the HD program forward.<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>About Huntington\u2019s Disease<\/strong><\/p>\n<p>HD is an incurable, hereditary brain disorder caused by a single defective gene on chromosome 4. As the disease affects different parts of the brain, it impacts movement, behavior, and cognition. It becomes harder to walk, think, reason, swallow, and talk. Eventually, the person will need full-time care. The complications associated with HD are usually fatal.<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>About NeuExcell Therapeutics<\/strong>.<\/p>\n<p>NeuExcell is a privately held early-stage gene therapy company headquartered in Pennsylvania, USA. Its mission is to improve the lives of patients suffering from neuro-degenerative diseases and CNS injuries. Based upon the scientific work of Prof. Gong Chen (Co-Founder and Chief Scientific Advisor), the Company has developed a potentially disruptive neural repair technology through in vivo astrocyte-to-neuron conversion by introducing neural transcription factors through adeno-associated virus (AAV)-based gene therapy. NeuExcell\u2019s pipeline covers major neurodegenerative diseases such as Stroke, Huntington\u2019s Disease, Amyotrophic Lateral Sclerosis (ALS), Alzheimer\u2019s Disease, Parkinson\u2019s Disease, Traumatic Brain Injury, Spinal Cord Injury, and Glioma.<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>About Spark Therapeutics<\/strong><br \/>\nAt\u00a0Spark Therapeutics, a fully integrated, commercial company committed to discovering, developing and delivering gene therapies, we challenge\u00a0the inevitability of genetic diseases,\u00a0including\u00a0blindness, hemophilia, lysosomal storage disorders and neurodegenerative diseases.\u00a0We currently have four programs in clinical trials.\u00a0At Spark, a member of the Roche Group, we see the path to a world where no life is limited by genetic disease. For more information, visit\u00a0<a href=\"http:\/\/www.sparktx.com\/\" target=\"_blank\" rel=\"noopener\">www.sparktx.com<\/a>, and follow us on\u00a0<a href=\"https:\/\/twitter.com\/spark_tx\" target=\"_blank\" rel=\"noopener\">Twitter<\/a>\u00a0and\u00a0<a href=\"https:\/\/www.linkedin.com\/company\/spark-therapeutics-inc\" target=\"_blank\" rel=\"noopener\">LinkedIn<\/a>.<\/p>\n<p>&nbsp;<\/p>\n<p><strong><u>NeuExcell Therapeutics <\/u><u>Media Contact<\/u>:<\/strong><\/p>\n<p>Xi Qin, MBA<br \/>\nChief Financial Officer<br \/>\nNeuExcell Therapeutics, Inc.<br \/>\n<a href=\"mailto:xiqin@neuexcell.com\">xiqin@neuexcell.com<\/a><br \/>\n814-826-5966<br \/>\n<a href=\"http:\/\/www.neuexcell.com\/\" target=\"_blank\" rel=\"noopener\">www.neuexcell.com<\/a><\/p>\n<p class=\"tags\">Tags: <a href=\"https:\/\/icrowdnewswire.com\/tag\/gene-therapy\/\" rel=\"tag noopener\" target=\"_blank\">Gene Therapy<\/a>, <a href=\"https:\/\/icrowdnewswire.com\/tag\/buinsess-development\/\" rel=\"tag noopener\" target=\"_blank\">Buinsess Development<\/a>, <a href=\"https:\/\/icrowdnewswire.com\/tag\/neuexcell\/\" rel=\"tag noopener\" target=\"_blank\">NeuExcell<\/a>, <a href=\"https:\/\/icrowdnewswire.com\/tag\/research-collaboration\/\" rel=\"tag noopener\" target=\"_blank\">Research collaboration<\/a>, <a href=\"https:\/\/icrowdnewswire.com\/tag\/milestone-payments\/\" rel=\"tag noopener\" target=\"_blank\">Milestone Payments<\/a>, <a href=\"https:\/\/icrowdnewswire.com\/tag\/huntingtons-disease\/\" rel=\"tag noopener\" target=\"_blank\">Huntington&#039;s disease<\/a>, <a href=\"https:\/\/icrowdnewswire.com\/tag\/spark-therapeutics\/\" rel=\"tag noopener\" target=\"_blank\">Spark Therapeutics<\/a> <\/p>\n<div><strong>See Campaign: <\/strong><a href=\"https:\/\/neuexcell.com\/\" target=\"_blank\" rel=\"noopener\">https:\/\/neuexcell.com\/<\/a><br \/><b>Contact Information:<\/b><br \/>Xi Qin, <a href=\"mailto:xiqin@neuexcell.com\">xiqin@neuexcell.com<\/a><\/p>\n<p><b>Tags:<\/b><br \/><a href=\"https:\/\/icrowdnewswire.com\/category\/menafn\/\" rel=\"category tag noopener\" target=\"_blank\">Menafn<\/a>, <a href=\"https:\/\/icrowdnewswire.com\/category\/ips\/\" rel=\"category tag noopener\" target=\"_blank\">IPS<\/a>, <a href=\"https:\/\/icrowdnewswire.com\/category\/reportedtimes\/\" rel=\"category tag noopener\" target=\"_blank\">Reportedtimes<\/a>, <a href=\"https:\/\/icrowdnewswire.com\/category\/google-news\/\" rel=\"category tag noopener\" target=\"_blank\">Google News<\/a>, <a href=\"https:\/\/icrowdnewswire.com\/category\/financial-content\/\" rel=\"category tag noopener\" target=\"_blank\">Financial Content<\/a>, <a href=\"https:\/\/icrowdnewswire.com\/category\/releaselive\/\" rel=\"category tag noopener\" target=\"_blank\">ReleaseLive<\/a>, <a href=\"https:\/\/icrowdnewswire.com\/category\/pr-wirein\/\" rel=\"category tag noopener\" target=\"_blank\">PR-Wirein<\/a>, <a href=\"https:\/\/icrowdnewswire.com\/category\/news-category\/extended-distribution\/\" rel=\"category tag noopener\" target=\"_blank\">Extended Distribution<\/a>, <a href=\"https:\/\/icrowdnewswire.com\/category\/news-category\/icn-internal-distribution\/\" rel=\"category tag noopener\" target=\"_blank\">iCN Internal Distribution<\/a>, <a href=\"https:\/\/icrowdnewswire.com\/category\/language\/english\/\" rel=\"category tag noopener\" target=\"_blank\">English<\/a><\/p>\n<\/div>\n<div>\n<h3>Contact Information:<\/h3>\n<p>Xi Qin, <a href=\"mailto:xiqin@neuexcell.com\">xiqin@neuexcell.com<\/a><\/p>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Using NeuExcell&rsquo;s neuroregenerative gene therapy platform, the collaboration aims to develop an effective and safe treatment for patients suffering from Huntington&rsquo;s Disease. Spark Therapeutic&rsquo;s excellence in R&amp;D and proprietary adeno-associated virus (AAV) vector gene therapy platform may advance the development of the program and overcome hurdles and challenges of viral vectors for gene therapy. NeuExcell [&hellip;] <a href=\"https:\/\/ipsnews.net\/business\/2021\/09\/07\/neuexcell-therapeutics-and-spark-therapeutics-announce-research-collaboration-agreement-to-develop-a-novel-gene-therapy-for-huntingtons-disease\/\" class=\"more-link\">Continue Reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":291,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-131747","post","type-post","status-publish","format-standard","hentry","category-press-release"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>NeuExcell Therapeutics and Spark Therapeutics Announce Research Collaboration Agreement to Develop a Novel Gene Therapy for Huntington\u2019s Disease - Business<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ipsnews.net\/business\/2021\/09\/07\/neuexcell-therapeutics-and-spark-therapeutics-announce-research-collaboration-agreement-to-develop-a-novel-gene-therapy-for-huntingtons-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NeuExcell Therapeutics and Spark Therapeutics Announce Research Collaboration Agreement to Develop a Novel Gene Therapy for Huntington\u2019s Disease - Business\" \/>\n<meta property=\"og:description\" content=\"Using NeuExcell&rsquo;s neuroregenerative gene therapy platform, the collaboration aims to develop an effective and safe treatment for patients suffering from Huntington&rsquo;s Disease. 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